So I've seen this on Beta, and here's what you need to know :
If you only have one each of your sentient goods manus (and don't have a level 13+ Simia Sapiens), it will be
literally impossible to gather some of the goods requirements in the tech tree.
If you have two of each, then you will probably eventually build up enough sentient goods (although good luck finding someone to trade enough with), but ... even with MMs, I think you'll run out of divine seeds[1]
Also, Portal Profits are going to be very little use (of course), guess Inno realised that they were too useful
Summary: This GR will take non-whale players a very long time, if they don't just give up in disgust at the ridiculous sentient goods requirements.
[1] Once upon a time, someone suggested that it would have been good if the very expensive Trader upgrades included extra divine seed production ... oh wait, that someone was me
Just saying, now is the time when it would be really nice to have some extra seed production going on ...