They all have some use. Whether that outweighs the tournament and spire penalty (and is better than investing in the alternative AWs which could be focussed on instead) is down to personal priorities. The C16 and C17 wonders are discussed on the corresponding threads. For me the C18 AW the "Temple of Spirits" will be a good source of Unurium. It won't really be needed until C19+ though.